Ph.D.Lan Xianyong, Professor
College of Animal Science and Technology,Northwest A&F University (NWSUAF),No. 22 Xinong Road, Yangling, Shaanxi Province, 712100, China
Telephone: +86-137-7207-1502
E-mail: lanxianyong79@nwsuaf.edu.cn or lan342@126.com
Education Background
1997-2001 B.S. Northwest Minority University, Husbandry and Veterinary Medicine.
2001-2004 M.S. Northwest A&F University, Animal Breeding, Genetics and Reproduction
2004-2007 Ph.D. Northwest A&F University,Genetics
MAR.2005-MAR.2006, Visiting Doctor-Candidate graduate in Institute of Infectious disease,Beijing Ditan Hospital
Visiting scholar JUL. 2008- OCT.2008 Visiting scholar in Wake Forest University, USA.
Post-Doc (Advanced visiting scholar ) NOV.2011-NOV.2012 Post-Doc (Advanced visiting scholar) in University of Wisconsin-Madison, USA
Teaching
Undergraduate Courses : (I) Animal Genetics; (II) Animal Gene Engineering ;(III）Innovation Training
Graduate Course: (I) Molecular Genetics; (II) Animal Cellular Genetics
Funds and Programs (Host)
Be in charge of the National Natural and Science Foundation of China(No.31872331), 2019.01-2022.12;
Be in charge of the National Natural and Science Foundation of China (No.31672400), 2017.01-2020.12;
Was in charge of the National Natural and Science Foundation of China (No.31172184),2012.01-2015.12;
Was in charge of the Young New Star Project on Science &Technology of Shaanxi Province (No.2011kjxx64), 2011.10-2014.10, funded by the government of Shaanxi Province.
Was in charge of the Natural Science Foundation of Shaanxi Province of China) (No.2011JQ3009), 2011.1-2013.12, funded by the government of Shaanxi Province.
Was in charge of the Young Topnotch Researcher Support Project of Northwest A&F University, No.QNGG-2009-007), 2009.10-2012.12, funded by the official committee of Northwest A&F University.
Publications (#Co-first authour; *corresponding author)
Yang Qing; Han Lin; Li Jie; Xu Han; Liu Xinfeng; Wang Xinyu; Pan Chuanying; Lei Chuzhao; Chen Hong; Lan Xianyong*. Activation of Nrf2 by phloretin attenuates palmitic acid-induced endothelial cell oxidative stress via AMPK-dependent signaling. Journal of Agricultural and Food Chemistry, Accepted on Dec.9, 2018（Manuscript ID: jf-2018-05025n.R2）(IF="3.417)
Yunyun Jin, Jian Wang, Meng Zhang, Sihuan Zhang, Chuzhao Lei, Hong Chen, Wei Guo, Xianyong Lan *. Role of miR-204 in the regulation of adipocyte proliferation, differentiation and apoptosis. Journal of Celluar Physiology, Accepted on October,2018; (Manuscript ID: JCP-18-1045). (IF="3.923)
Xinyu Wang, Qing Yang, Ke Wang, Hailong Yan, Chuanying Pan, Hong Chen, Jinwang Liu, Haijing Zhu, Lei Qu, Xianyong Lan *. Two strongly linked single nucleotide polymorphisms (Q320P and V397I) in GDF9 gene are associated with litter size in cashmere goats. Theriogenology, 2019,125:115-121.
Bao zhang#, Liao Chang#, Xianyong Lan#, Nadeem Asif, Fanglin Guan, Kedong Fu, Bo Li, Xiachun Yan, Hongzhang Bo, Zhang Xiaoyan, Huang Yongzhen, Chen Hong, Yu Jun*, Li Shengbin*. Genome-wide definition of selective sweeps reveals molecular evidence of trait-driven domestication among elite goat (Capra species) breeds for the production of dairy, cashmere, and meat. GigaScience, 2018, Doi: 10.1093/gigascence/giy105 (#These authors contributed equally to this work.）(IF="7.24)
Ma Lin, Zhang Meng, Jin Yunyun, Sarantsetseg Erdenee, Hu Linyong, Chen Hong Cai Yong*, Xianyong Lan*. Comparative transcriptome profiling of mRNA and lncRNA related to tail adipose tissues of sheep. Frontiers in Genetics, 2018, 9: 365. DOI: 10.3389/fgene.2018.00365.
Cui Y#, Yan H#, Wang K, Xu H, Zhang X, Zhu H, Liu J, Qu L, Lan X* and Pan C*. (2018) Insertion/Deletion within the KDM6A gene is significantly associated with litter size in goat. Front. Genet. 9: 91. doi: 10.3389/fgene.2018.00091.
Xiaoyan Zhang, Shuai Yu, Qing Yang, Ke Wang, Sihuan Zhang, Chuanying Pan, Hailong Yan, Ruihua Dang, Chuzhao Lei, Hong Chen, Xianyong Lan*. Goat Boule: Isoforms identification, mRNA expression in testis and functional study and promoter methylation profiles. Theriogenology, 2018, 116:53-63.
Ma Lin, Li Zhaozhong, Cai Yong, Xu Hongwei, Yang Ruolin*, Lan Xianyong*. Genetic variants in fat and short tailed sheep from high-throughput RNA-sequencing data. Animal Genetics, 2018, 49(5): 483-487. DOI: 10.1111/age.12699.
Sihuan Zhang, Han Xu, Zihong Kang, Hanfang Cai, Ruihua Dang, Chuzhao Lei, Hong Chen, Xian Guo*, Xianyong Lan*. bovine PITX2 gene：Identification, characterization and mRNA expression analysis and association ananlysis. Gene, 2018, 669: 1-7.
Jie Li, Shaoli Zhang, Sarantsetseg Erdenee, Xiuzhu Sun, Ruihua Dang, Yongzhen Huang, Chuzhao Lei, Hong Chen, Hongwei Xu, Yong Cai, Xianyong Lan*. Nucleotide variants in prion-related protein (testis-specific) gene (PRNT) and effects on Chinese and Mongolian sheep phenotypes. Prion, 2018, 12(3-4):185-196. DOI: 10.1080/19336896.2018.1467193.
Jie Li, Sarantsetseg Erdenee, Shaoli Zhang, Zhenyu Wei, Meng Zhang, Yunyun Jin, Hui Wu, Hong Chen, Xiuzhu Sun, Hongwei Xu, Yong Cai, Xianyong Lan*. Genetic effects of PRNP gene insertion/deletion (indel) on phenotypic traits in sheep. Prion, 2018, 12(1): 42-53. doi: 10.1080/19336896.2017.1405886.
Yunyun Jin, Qing Yang, Jiayang Gao, Qi Tang, Bo Duan, Ting Yu, Xinglei Qi, Jiming Liu, Rongmin Wang, Ruihua Dang, Chuzhao Lei, Hong Chen, Xianyong Lan*. Detection of insertions/deletions within SIRT1, SIRT2 and SIRT3 genes and their associations with body measurement traits in cattle. Biochemical Genetics, 2018, 56(6):663-676.
Wang Xinyu#, Yang Qing#, Wang Ke, Zhang Sihuan, Chuanying Pan, Hong Chen, Qu Lei, Yan Hailong*, Lan Xianyong*. A novel 12-bp indel polymorphism within the GDF9 gene is significantly associated with litter size and growth traits in goats. Animal Genetics, 2017, 48(6): 735-736 .
Qing Yang#, Hailong Yan#, Jie Li, Han Xu, Ke Wang, Haijing Zhu, Hong Chen, Lei Qu*, Xianyong Lan*. A novel 14-bp duplicated deletion within goat GHR gene is significantly associated with growth traits and litter size. Animal Genetics, 2017 , 48(4): 499-500.
Xiaoyan Zhang#, Sihuan Zhang#, Lin Ma, Enhui Jiang, Han Xu, Rui Chen, Qing Yang, Hong Chen, Zhuangjian Li*, Xianyong Lan*. Reduced representation bisulfite sequencing (RRBS) of dairy goat mammary glands reveals DNA methylation profiles of integrated genome-wide and critical milk-related genes. Oncotarget, 2017, 2017: 8(70): 115326-115344.
Zhuanjian Li #, Xianyong Lan #, Ruili Han*, Jing Wang, Yongzhen Huang, Jiajie Sun, Wenjiao Guo, Hong Chen*. miR-2478 inhibits TGFβ1 expression by targeting the transcriptional activity region downstream of the TGFβ1 promoter in dairy goats. Scientific Reports, 2017, 7: 42627.
Zhang Sihuang, Xu Han, Liu Xinfeng, Yang Qing, Pan Chuanying, Lei Chuzhao, Dang Ruihua, Chen Hong, Lan Xianyong*. The muscle development transcriptome landscape of ovariectomized goat. Royal Sciety Open Science, 2017, 4:171415.
Li Jie#, Zhu Xichun#, Ma Lin, Xu Hongwei, Cao Xin, Luo Renyun, Chen Hong, Sun Xiuzhu, Cai Yong*, Lan Xianyong*. Detection of a new 20-bp insertion/deletion (indel) within sheep PRND gene using mathematical expectation (ME) method. Prion, 2017, 11(2):143-150.
Qing Yang, Sihuan Zhang, Liangliang Liu, Chuzhao Lei, Xinglei Qi, Fengpeng Lin, Weidong Qu, Xingshan Qi, Jiming Liu, Rongmin Wang, Hong Chen*, Xianyong Lan*. The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds. Journal of applied animal research. 2017, 46(1): 505-511.
Qing Yang, Sihuan Zhang, Xiukai Cao, Liangliang Liu, Chuzhao Le, Xinglei Qi, Fengpeng Lin, Weidong Qu, Xingshan Qi, Hong Chen*, Xianyong Lan*. Application of mathematical expectation (ME) strategy on detecting the low frequency mutation: An example for evaluating 14 bp indel of the PRNP gene 3’ UTR in four Chinese indigenous cattle breeds. Prion, 2016, 10(5): 409-419.
Sihuan Zhang, Hanfang Cai, Qing Yang, Tao Shi, Chuanying Pan, Chuzhao Lei, Ruihua Dang, Hong Chen, Xianyong Lan*. Novel alternative splicing transcripts identification and expression analysis of bovine TMEM95 gene. Gene, 2016, 575 (2): 531-536.
Sihuan Zhang#, Xianfeng Wu#, Chuanying Pan, Chuzhao Lei, Ruihua Dang, Hong Chen, Xianyong Lan*. Identification of novel isoforms of dairy goat EEF1D and their mRNA expression characterization. Gene, 2016,581(1):14-20.
Xiaoyan Zhang, Sihuan Zhang, Qing Yang, Chuzhao Lei, Hong Chen*, Xianyong Lan*. Exploration of dairy goat PITX2 alternative splice events and differential isoform expression. Small Ruminant Research, 2016, 144: 140-144.
Jia Wenchao, Wu Xianfeng, Li Xiangcheng, Xia Tian, Hong Chen, Chuanying Pan, Xianyong Lan*. Novel genetic variants associated with mRNA expression of STAT3 gene significantly affected goat growth traits, 2015, Small Ruminant Research, 2015,129: 25-36 .
Xiaoyan Zhang, Yang Zhou, Chuanying Pan, Chuzhao Lei, Ruihua Dang, Hong Chen, Xianyong Lan*. Novel alternative splice variants of NFIX and their diverse mRNA expression patterns in dairy goat. Gene, 2015, 569:250-258 .
Sihuan Zhang, Yonglong Dang, Qingfeng Zhang, Qiaomei Qin, Chuzhao Lei, Hong Chen, Xianyong Lan*. Tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) rapidly identified a critical missense mutation (P236T) of bovine ACADVL gene significantly affecting growth traits. Gene, 2015, 559:184-188.
Wu Xianfeng, Jia Wenchao, Zhang Jingjing, Li Xiangcheng, Pan Chuanying, Lei Chuzhao, Chen Hong, Dang Ruihua, Lan Xianyong*. Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds. Small Ruminant Research, 2014, 121:232-243.
Lan X, Cretney EC, Kropp J, Khateeb K, Berg M, Peñagaricano F, Magness R, Radunz A* and Khatib H*. Maternal diet during pregnancy induces gene expression and DNA methylation changes in fetal tissues in sheep. Front. Genet. 2013,4:49.
Lan XY, Peñagaricano F, Dejung L, Weigel KA, Khatib H*. A missense mutation in the PROP1 (prophet of Pit 1) gene affects male fertility and milk production traits in the US Holstein population. Journal of Dairy Science, 2013, 96(2):1255-1257.
Xianyong Lan#, Haiyu Zhao#, Zhuanjian Li, Rui Zhou, Xingwu Jiang, Chengsheng Han, Chuanying Pan, Chuzhao Lei, Hong Chen*. Exploring novel genetic variant of PITX1 gene and its effect on milk performance in dairy goats. Journal of Integrative Agriculture, 2013, 12(1): 118-126.
Haiyu Zhao, Xianfeng Wu, Hanfang Cai, Chuanying Pan, Chuzhao Lei, Hong Chen, Xianyong Lan*. Genetic variants and effects on milk traits of the caprine paired-like homeodomain transcription factor 2 (PITX2) gene in dairy goats. Gene, 2013, 532(2): 203-210.
Chuanying Pan, Chongyang Wu, Wenchao Jia, Yao Xu, Shenrong Hu, Chuzhao Lei, Xianyong Lan*, Hong Chen. A critical functional missense mutation (H173R) in the bovine PROP1 gene significantly affects growth traits in cattle. Gene, 2013, 531(1):398-402 .
Zhuanjian Li#, Xianyong Lan#, Wenjiao Guo, Jiajie Sun, Yongzhen Huang, Jing Wang, Tinghua Huang, Chuozhao Lei, Xingtang Fang, Hong Chen*. Comparative transcriptome profiling of dairy goat microRNAs from dry period and peak lactation mammary gland tissues. PLoS ONE, 2012, 7(12): e52388 .
X.Y. Lan#, H.Y. Zhao#, Z.J. Li, A.M. Li, C.Z Lei, H. Chen**, C.Y. Pan. A novel 28-bp insertion–deletion polymorphism within goat PRNP gene and its association with production traits in Chinese native breeds. Genome, 2012,55(7):547-552
Xianyong Lan, Xinsheng Lai, Zhuanjian Li, Jing Wang, Chuzhao Lei,Hong Chen**. Effects of genetic variability of the caprine homeobox transcription factor HESX1 gene on performance traits. Molecular Biology Reports, 2010, 37:441-449
Xianyong Lan, Chuanying Pan, Yuanwen Guo, S. Hua, J. Wang, Y.B. Liu, S.R. Hu, C.Z. Lei, H. Chen*. Twelve novel SNPs of the goat POU1F1 gene and their associations with cashmere traits. Small Ruminant Research, 2009, 85:116-121.
Xianyong Lan, Chuanying Pan, Liangzhi Zhang, Miao Zhao, Chunlei Zhang, Chuzhao Lei, Hong Chen* . A novel missense (A79V) mutation of goat PROP1 gene and its association with production traits. Molecular Biology Reports, 2009, 36(8): 2069-2073.
XY Lan, CY Pan, H Chen*, CZ Lei, FY Li, HY Zhang, YS Ni. Association of novel SNP of goat Prolactin (PRL) gene with cashmere traits. Journal of applied genetics. 2009, 50 (1): 51-54.
Jing Yongjie#, Xianyong Lan#, Chen Hong*, Liangzhi Zhang, Chunlei Zhang, Chuanying Pan, Mijie Li, Gang Ren, Tianbao Wei, Miao Zhao. Three novel single nucleotide polymorphisms (SNPs) of the LHX3 gene in bovine. Journal of Biosciences, 2008, 33 (5): 673–679.
Lan XY, Pan CY, Chen H*, Lei CZ. (2007).A DdeI PCR-RFLP detecting genetic variation of goat POU1F1 gene. Canadian Journal of Animal Science, 87(1): 13-14.
XY Lan, CY Pan, H Chen*, CL Zhang, JY Li, M Zhao, CZ Lei, AL Zhang, L Zhang. (2007). An AluI PCR-RFLP detecting a silent allele at the goat POU1F1 locus and its association with production traits. Small Ruminant Research, 73：8-12.
Chen N#, Cai Y#, Chen Q#, Li R#, Wang K#, Huang Y#, Hu S, Huang S, Zhang H, Zheng Z, Song W, Ma Z, Ma Y, Dang R, Zhang Z, Xu L, Jia Y, Liu S, Yue X, Deng W, Zhang X, Sun Z, Lan X, Han J, Chen H, Bradley DG, Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia.Nat Commun. 2018 Jun 14;9(1):2337. doi: 10.1038/s41467-018-04737-0.
Chen R, Cui Y, Zhang X L, Zhang Y H, Chen M Y, Zhou T, Lan X Y, Dong W Z, Pan C Y*. Chlorpyrifos Induction of Testicular-Cell Apoptosis through Generation of Reactive Oxygen Species and Phosphorylation of AMPK. J Agric Food Chem. 2018, 66: 12455-12470. (DOI: 10.102/ACS.JAFC.8B0307)
Wei X, Li H, Zhao G, Yang J, Li L, Huang Y, Lan X, Ma Y, Zheng H, Chen H. ΔFosB regulates rosiglitazone-induced milk fat synthesis and cell survival. J Cell Physiol. 2017 Nov 20. doi: 10.1002/jcp.26218. [Epub ahead of print] PMID:29154466
Li H, Yang J, Wei X, Song C, Dong D, Huang Y, Lan X, Plath M, Lei C, Ma Y, Qi X, Bai Y, Chen H. CircFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a. J Cell Physiol. 2017 Oct 18. doi: 10.1002/jcp.26230. [Epub ahead of print]
Yang Q, Zhang SL, Li J, Wang XY, Peng K, Lan XY, Pan CY*. Development of a touch-down multiplex PCR method for simultaneously rapidly detecting three novel insertion/deletions (indels) within one gene: an example for goat GHR gene. 2018. Animal Biotechnology. Doi：10.1080/10495398.2018.1517770. https://doi.org/10.1080/10495398.2018.1517770.
Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Cell Death Dis. 2017 Oct 26;8(10):e3153. doi: 10.1038/cddis.2017.541.
Chen R, Du J, Ma L, Wang LQ, Xie SS, Yang CM, Lan XY, Pan CY*, Dong WZ*. Comparative microRNAome analysis of the testis and ovary of the Chinese giant salamander. Reproduction. 2017,154: 169-179
Wei X, Li H, Zhang B, Li C, Dong D, Lan X, Huang Y, Bai Y, Lin F, Zhao X, Chen H. miR-378a-3p promotes differentiation and inhibits proliferation of myoblasts by targeting HDAC4 in skeletal muscle development. RNA Biol. 2016 Dec;13(12):1300-1309. Epub 2016 Sep 23.
Li M, Sun X, Cai H, Sun Y, Plath M, Li C, Lan X, Lei C, Lin F, Bai Y, Chen H. Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204. Biochim Biophys Acta. (BBA-Gene Regulatory Mechanisms), 2016,1859(7):871-82（SCI, IF="5.373）.
Xiaomei Sun, Mingxun Li, Yujia Sun, Hanfang Cai, Xianyong Lan, Yongzhen Huang, Yueyu Bai, Xinglei Qi, Hong Chen. The developmental transcriptome sequencing of bovine skeletal muscle reveals a long noncoding RNA, lncMD, promotes muscle differentiation by sponging miR-125b. BBA - Molecular Cell Research, 2016, 1863(11): 2835-2845.
Zhang BW, Cai HF, Wei XF, Sun JJ, Lan XY, Lei CZ, Lin FP, Qi XL, Plath M, Chen H. miR-30-5p Regulates Muscle Differentiation and Alternative Splicing of Muscle-Related Genes by Targeting MBNL. Int J Mol Sci. 2016 Jan 29;17(2). pii: E182. doi: 10.3390/ijms17020182.
Cai H, Zhou Y, Jia W, Zhang B, Lan X, Lei C, Fang X, Chen H. Effects of SNPs and alternative splicing within HGF gene on its expression patterns in Qinchuan cattle. J Anim Sci Biotechnol. 2015 Dec 22;6:55. doi: 10.1186/s40104-015-0059-3. eCollection 2015.
Wang X, Lan X, Radunz AE, Khatib H*. Maternal nutrition during pregnancy is associated with differential expression of imprinted genes and DNA methyltranfereases in muscle of beef cattle offspring. J Anim Sci. 2015, 93(1):35-40.
J. Wang, L.S. Hua, H. Pan, L.Z. Zhang, M.X. Li, Y.Z. Huang, X.Y. Lan, C.Z. Lei and H. Chen*. Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle. Scientific Reports，2015，5：720
Mingxun Li，Xiaomei Sun，Yang Zhou，Xuefeng Wei，Yujia Sun，Xianyong Lan，Chuzhao Lei，Hong Chen*. Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism. Journal of Functional Foods, 2015(18): 492-500
Sun X, Li M, Sun Y, Cai H, Li R, Wei X, Lan X, Huang Y, Lei C, Chen H*. The developmental transcriptome landscape of bovine skeletal muscle defined by Ribo-Zero ribonucleic acid sequencing. J Anim Sci, 2015，93(12)：5648-5658
Liangzhi Zhang, Shangang Jia, Mingjuan Yang, Yao Xu, Congjun Li, Jiajie Sun, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yang Zhou, Chunlei Zhang, Xin Zhao, Hong Chen. Detection of Copy Number Variations and Their Effects in Chinese Bulls. BMC Genomics，2014, 15：480
