Dr. Jiang Yu
Professional Title: Professor and PI of Agriculture Animal Genomics Lab
Research Field:Animal Genomics
Date of Birth:Dec. 1983
Cell phone: +86 15029266711
Email: jiangyu9 6@163.com; yu.jiang@nwafu.edu.cn
Address: College of Animal Science and Technology,
Northwest A&F University, Yangling, Shaanxi, 712100
Lab website：http://animal.nwsuaf.edu.cn/
EDUCATION and WORKING
2015.5 - present Professor in College of Animal Science and Technology, Northwest A&F University
2013.11-2015.4 Associate Professor in College of Animal Science and Technology, Northwest A&F University
2011.8 - 2013.8 Postdoctoral Fellow- Genome Sequence Analyst, CSIRO Livestock Industries
2006.9 - 2011.7 Ph.D., State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, CAS, China
2002.9 - 2006.7 B.Sc. of Biotechnology, College of Life Science,Fudan University, China
RESEARCH INTERESTS
Our major interests lie in the Agriculture animals and their genomic and genic changes in domestication process, especially for the ruminant livestock, such as sheep, goat and cow. In order to explore the agronomic traits related genes, explain their molecular mechanism then support breeding, we generate and assembly the sheep and goat reference genome, re-sequencing more breeds and their wild relatives, get large-scale re-sequencing and RNA-seq data for comparative genomics analysis and whole genome association study. Firstly, we search all of functional variations, such as SNPs and CNVs. Then using GWAS studies combined with multiple evolutionary and comparative genomics tools and methods, we try to get the key genomic regions under artificial or nature selection and focus on meat, fertility, wool and environment adaptation related/causative variations.
GRANTS
PI of Hundred Talents Program in Shaanxi province,￥0.5 million, funded by Shaanxi province, China (2015-2016)
PI of the project "Evolutionary genomics analysis in Oula-type Tibetan sheep: finding the genes underlying high-altitude adaptation”,￥0.77 million , funded by the National Natural Science Foundation of China (2016-2019)
PI of the project "The Pan Caprinae Genome Plan",￥6 million, funded by "Thousand Youth Talents Plan" and Northwest A & F University (2016-2020)
PI of Outstanding young training Fellowship,￥0.4 million, funded by Northwest A & F University, China (2015-2017)
PI of Technology New Star Funds,￥0.1 million, funded by Science and Technology Department, Shaanxi province, China (2015-2016)
PI of Talent Start up Funds,￥0.5 million, funded by Northwest A & F University, China (2014-2016)
PI of the project "Sheep genomics and molecular breeding”, ￥2.6 million，funded by National Excellent Youth Science Foundation Project of China and Northwest A & F University (2019-2021)
AWARDS
2018 Finalists of " National Science Fund for Excellent Yong Scholars ", China 2018 Outstanding young agricultural scientists, China
2015 Finalists of "Thousand Youth Talents Plan" in China
2014 "Technology New Star" in Shaanxi province, China
2014 Reward-gainers of the excellent PhD dissertations in CAS, China
2011 ZhuLiYueHua Scholarship in CAS, China
PUBLICATIONS
Main contributed papers (# Co-first author, *Co-corresponding author)
1. Li D#, Dong Y#, Jiang Y#, Jiang HF#, Cai J, Wang W*, A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Research 20(4)(2010),408-420.
2. Jiang Y#, Li Y#, Lee W#, Xu X, Zhang Y, Zhao R, Zhang Y*, Wang W*, Venom gland transcriptomes of two elapid snakes (Bungarus multicinctus and Naja atra) and evolution of toxin genes. BMC Genomics 12(1) (2011), 1-13.
3. Dong Y#, Xie M#, Jiang Y#…, Wang J*, Wang W*, Sequencing and automated whole-genome optical mapping of the genome of a domestic goat. Nature Biotechnology 31(2) (2013): 135-141 (ESI Highly Cited Papers)
4. Jiang Y#, Xie M#, Chen W#…, Wang W*, Dalrymple B*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science 344 (2014): 1168-1172. (ESI Highly Cited Papers)
5. Zhou Z#, Jiang Y#, Wang Z#…, Wang W*, Tian Z*. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology 23(4) (2015): 408-414 (ESI Highly Cited Papers)
6. Jiang Y#, Wang X#, Kijas J, Dalrymple B*. Beta globin gene evolution in the ruminants: evidence for an ancient origin of sheep haplotype B. Animal Genetics (2015) 46: 506–514
7. Dong Y#, Zhang X#, Xie M#…, Wang W*, Jiang Y*Reference genome of wild goat (Capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics (2015), 16:431
8. Chen H, Jiang Y*, Progress and Prospects in Domestic Animals and Breeding: a Review of Genomic Copy Number Variations. Biotechnology Bulletin (2015) 31(11): 35-42.
9. Li M, Zhou H, Pan X, …, Zi X*, Jiang Y*, Cassava foliage affects the microbial diversity of Chinese indigenous geese caecum using 16S rRNA sequencing[J]. Scientific Reports, 2017, 7.
10.Wang X, Zheng Z, Cai Y, Chen T, Li C, Fu W, Jiang Y*. CNVcaller: Highly Efficient and Widely Applicable Software for Detecting Copy Number Variations in Large Populations. GigaScience, 2017.12.4, 6(12)
11.#Chen N, #Cai Y, #Chen Q,..., Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and multiple adaptive introgression events of domesticated cattle in East Asia. Nature communications ,2018, 9 (1), 2337.
12.#Zhou Z, #Li M, #Cheng H,..., Hou S*, Jiang Y*. An intercross population study reveals genes associated with body size and plumage color in ducks. Nature communications ,2018,9,2648.
13.Wang X, Liu J, Niu Y, ,..., Jiang Y*, Chen Y* Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep. BMC genomics (2018).
Other contributed papers:
1. Ding Y, Zhao L, Yang S, Jiang Y, et al. A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y-linked Male Fertility Genes. PLoS Genet 2010 6(12): e1001255
2. Gonzalez M, Mousel M, Herndon D, Jiang Y, et al. A MYADM-like Variant Gene is Associated with Erythrocyte Traits and Weight of Lamb Weaned in Domestic Sheep. PloS one 2013 8 (8), e74700
3. Wang Y, Wu J, Ma X, Liu B, Su R, Jiang Y, Wang W, Dong, Y. Single Base-Resolution Methylome of the Dizygotic Sheep. PloS one, 2015 10 (11), e0142034
4. Wang, X., Yu, H., Lei, A., Zhou, J., Zeng, W., Zhu, H…, Jiang Y & Chen, Y., Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system. Scientific reports 2015. 5.
5. Gao Y, Wang X, Yan H…, Jiang Y & Chen, Y., Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats[J]. PloS one, 2016, 11(3): e0151118.
6. Wang X, Liu J, Zhou G…, Jiang Y & Chen, Y., Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits[J]. Scientific Reports, 2016, 6.
PRESENTATIONS
Invited presentations in international conferences
1. "The progress of sheep and goat genome assembly” May 13-14, 2010, Shenzhen, China.International Conference of 1000 Plant and Animal Reference Genomes Project
2."Sequencing and assembly of the sheep reference genome”Plant & Animal Genomes XIX Conference, Jan 15-19, 2011 San Diego, US.
3."High-Resolution Analysis of Allelic Expression in Seven Sheep tissues”Plant & Animal Genomes XIX Conference, Jan 15-19, 2011 San Diego, US.
4."Sheep Genome Project: Gap Filling and Unbalanced Allelic Expression”Plant & Animal Genomes XX Conference, Jan 14-18, 2012 San Diego, US.
5."The quality of sheep reference genome, OAR v3.1”5th 3SR Consortium Meeting, June 28-29, Alghero, Italy
6."A reference genome of the domestic goat”33rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
7."The imprintome of a domestic sheep”33rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
8."The domestic sheep reference genome assembly”33rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
9."Detection of large-scale variation among sheep goat and cattle genomes”34th International Society for Animal Genetics, July 27-31, 2014, Xi'an, China
10."Comparative genomics analysis provides new insights to ruminant biology ”9th International Conference on Genomics, Sep 9-12, 2014, Shenzhen, China
11."Construction and evaluation of the Caprinae Pan-genome Livestock genomics meeting, Sep 14-16, 2016, Cambridge, UK
12. "The ruminant biology and evolution revealed by a flock of ruminant de novo genomes” 36th International Society for Animal Genetics, July 17-21, 2017, Dublin, Ireland
13."world-wide ancestry and multiple adaptive introgression events of domesticated cattle” Fossils and Ancient Genomics Symposium, Apr 17, 2018, Shenzhen, China
