CURRICULUM VITAE
1.BASIC INFORMATION
2.EDUCATION
Aug. 2003 – Jun. 2006 Doctor Degree of Medicine, College of Pharmacy, the Fourth Military Medical University, Xi'an, China
Major Pharmacology
Sept. 2000 – Jul. 2003 Master Degree of Medicine, College of Pharmacy, Xi'an Jiaotong University, Xi'an, China
Major Pharmacognosy
Sept. 1996 – Jul. 2000 Bachelor Degree of Science, College of Pharmacy, Xi'an Jiaotong University, Xi'an, China
Major Pharmacy
3.WORK EXPERIENCE
Apr. 2017 – present Dean of Department of Pharmacy, School of Chemistry and Pharmacy, Northwestern A&F University, China
Nov. 2016 – presentProfessor, School of Chemistry and Pharmacy, Northwestern A&F University, China
Jul. 2014 – Oct. 2016 Vice Director, Department of Natural Medicine and Institute of Materia Medica, the Fourth Military Medical University, China
Mar. 2012 – Aug. 2013 Postdoctoral Fellow, Department of Health Sciences, Lakehead University, Canada
Jul. 2011 – Oct. 2016 Associate Professor, Department of Natural Medicine and Institute of Materia Medica, the Fourth Military Medical University, China
Sept. 2009 – May 2011 Instructor, Department of Natural Medicine and Institute of Materia Medica, the Fourth Military Medical University, China
Jun. 2006 –Aug. 2009 Instructor, Department of Pharmacology, the Fourth Military Medical University, China
4.GRANTS (Principal Investigator)
1. The Major Applied Research Programs of YanglingDistrict (2017CXY-19) 01/01/2017 – 12/31/2019
Title: The study of a new drug from Holotrichia diomphalia Bates against liver cancer
2. The Talent Research Programs of Northwestern A&F University 01/01/2017 – 12/31/2019
Title: Study on the anti-hepatocarcinoma effect and molecular mechanism ofsulfated oligosaccharide by targeting ALDOA
3. The Major Applied Research Programs of S&T Program of Shaanxi Province(2015KTZDSF02-01-02) 01/01/2015 – 12/31/2017
Title: The study of an anti-glioma TCM new drug, bufotalin liposome
4. Science and Technology Program of Shaanxi Province (2015XT-02) 01/01/2015 – 12/31/2017
Title: The pre-clinical study on the new Chinese medicine ‘Jiaoe Mixture’
5. The Research Project from Shaanxi Province Administration of TCM (13-ZY037) 01/01/2014 – 12/31/2015
Title: The key technologyof the genetic diversity, antitumor active components of Qinling Qiyao
6. The National Natural Science Foundation of China (81173513) 01/01/2012 – 12/31/2015
Title: The core fragments' structure of Angelica acidic polysaccharides regulating Galectin-3-mediated apoptosis in leukemia cells and the QSAR
7. Science and Technology Program of Shaanxi Province (2012KJXX-21) 01/01/2012 – 12/31/2013
Title: The study on the antitumor active components of Holotrichia diomphalia Bates
8. The Key Technologies R & D Program of Shaanxi Province (2010k12-01-02) 01/01/2010 – 12/31/2011
Title: The study of a TCM newdrug, Shuangsu dispersible tablet for the treatment of migraine
9. National Science and Technology Major Program (2009ZXJ09301-009-PJ07) 09/01/2009 – 12/31/2011
Title: Studies on the new drug of Xinan soft capsule and the treatment for fatty liver
10. The National Natural Science Foundation of China (30701081) 01/01/2008 – 12/31/2010
Title: Studies on the relationship of the structure and antitumor activity of the fragments obtained by enzymatic hydrolysis of angelica polysaccharide APS-3b
5.REPRESENTATIVEPUBLICATIONS
1. Liu W, Li W, Sui Y, Li XQ, Liu C, Jing H, Zhang H, Cao W*. Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica sinensis (Oliv.) Diels. Int J Biol Macromol. 2018;121:161-172. (IF 4.11)
2. Cao W, Chang T, Li XQ, Wang R, Wu L. Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB upregulation and vascular remodeling. Clin Sci (Lond). 2017, 131(4):309-325 (Q1 [Top],IF 5.016)
3. Li XQ, Tian W, Liu XX, Zhang K, Huo JC, Liu WJ, Li P, Xiao X, Zhao MG, Cao W*. Corosolic acid inhibits the proliferation of glomerular mesangial cells and protects against diabetic renal damage. Scientific Reports2016, 6:26854(Q1 [Top], IF 5.228)
4. Li XQ, Liu XX, Wang XY, Xie YH, Yang Q, Liu XX, Ding YY, Cao W*, Wang SW. Cinnamaldehyde Derivatives Inhibited Coxsackievirus B3-Induced Viral Myocarditis. Biomol Ther (Seoul) 2017, 25(3):279-287 (IF 2.127)
5. Zhao H, Yuan J, Yang Q, Xie Y, Cao W*, Wang S*. Cinnamaldehyde in a Novel Intravenous Submicrometer Emulsion: Pharmacokinetics, Tissue Distribution, Antitumor Efficacy, and Toxicity. J Agric Food Chem. 2015, 63(28):6386-6392 (Q1 [Top], IF 3.107)
6. Li WY, Li P, Li XQ, Huang H, Yan HW, Zhang Y, Cao W*. Simultaneous Quantification of Uronic Acid, Amino Sugar, and Neutral Sugar in the Acidic Polysaccharides Extracted from the Roots of Angelica sinensis (Oliv.) Diels by HPLC. Food Anal Methods. 2015, 8:2087–2093 (IF 2.167)
7. Zhou X, Yang Q, Xie Y, Sun J, Hu J, Qiu P, Cao W*, Wang S*.Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1.Neurobiol Aging. 2015,36(3):1462-70. (Q1 [Top], IF 5.153)
8. Li Y, Yuan J, Yang Q, Cao W*, Zhou X, Xie Y, Tu H, Zhang Y, Wang S. Immunoliposome co-delivery of bufalin and anti-CD40 antibody adjuvant induces synergetic therapeutic efficacy against melanoma. Int J Nanomedicine. 2014, 9:5683-700. (Q1 [Top], IF 4.383)
9. Li Y, Zhao H, Duan L, Li H, Yang Q, Tu H, Cao W*, Wang S*. Preparation, characterization and evaluation of bufalin liposomes coated with citrus pectin. Colloid Surface A. 2014, 444(5): 54-62 (IF 2.108)
10. Zhao H, Xie Y, Yang Q, Cao Y, Tu H, Cao W*, Wang S. Pharmacokinetic study of cinnamaldehyde in rats by GC-MS after oral and intravenous administration. J Pharmaceut Biomed. 2014, 89: 150-7 (IF 2.947)
11. Chen Y, Cao Y, Xie Y, Zhang X, Yang Q, Li X, Sun J, Qiu P, Cao W*, Wang S*. Traditional Chinese medicine for the treatment of primary dysmenorrhea: how do Yuanhu painkillers effectively treat dysmenorrhea? Phytomedicine. 2013, 20(12):1095-104 (IF 2.972)
12. Zhou X, Yang Q, Xie Y, Sun J, Qiu P, Cao W*, Wang S*. Protective effect of tetrahydroxystilbene glucoside against D-galactose induced aging process in mice. Phytochem Lett. 2013, 6(3): 372-8 (IF 1.179)
13. Zhang Y, Cao W*, Xie YH, Yang Q, Li XQ, Liu XX, Wang SW*. The comparison of α-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms. Int Immunopharmacol. 2012, 14(1):107-13. (IF 2.417)
14. Zhang XK, Xie YH, Cao W*, Yang Q, Miao S, Wang SW*. Brain distribution study of imperatorin in rats after oral administration assessed by HPLC. Chromatographia. 2011, 74(3-4):259-265. (IF 1.195)
15. Cao W, Xie YH, Li XQ, Zhang XK, Chen YT, Kang R, Chen X, Miao S, Wang SW. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic Res Cardiol. 2011, 106(6):1207-20. (Q1, IF 7.348)
16. Cao W, Li XQ, Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine. 2010, 17(8-9):598-605. (IF 2.972)
17. Cao W, Li XQ, Wang X, Li T, Chen X, Liu SB, Mei QB. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels. Int J Biol Macromol. 2010, 46(1): 115-22. (IF 2.453)
18. Cao W, Li XQ, Zhang XN, Hou Y, Zeng AG, Xie YH, Wang SW. Madecassoside suppresses LPS-induced TNF-α production in cardiomyocytes through inhibition of ERK, p38, and NF-κB activity. Int Immunopharmacol. 2010,10(7): 723-729. (IF 2.417)
19. Cao W, Li XQ, Liu L, Yang TH, Li C, Fan HT, Jia M, Lv Z, Mei Q. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbiohyd Polym, 2006,66(2): 149-59. (Q1, IF 3.628)
20. Cao W, Li XQ, Liu L, Wang M, Fan HT, Li C, Lv Z, Wang X, Mei Q. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbiohyd Res, 2006, 341(11): 1870-7. (IF 2.332)
6.AWARDS
1. Science and Technology Award (The first prize). The Government of Shaanxi Province. 2016
2. Science and Technology Award (The Second prize). The Government of Shaanxi Province. 2015
3. Outstanding Scholars Award. The Fourth Military Medical University. 2015
4. Outstanding Paper Award for National Youth Pharmaceutist (The first prize). China Medicine Education Association. 2014
5. Young Scholars Award. Science and Technology Department of Shaanxi Province. 2012
6. Science and Technology Award (The first prize). The Government of Shaanxi Province. 2012
7. Science and Technology Award (The first prize). The Government of Shaanxi Province. 2007
8. Outstanding Paper Award. Chinese Pharmaceutical Association. 2005
7.GRANTED PATENTS
1. Cao W, Wang S, Li Y. Bufalin liposome, preparation method therefor and application thereof (USA, US 9814734B2)
2. Cao W, Wang S, Li X, Shen X, Xie Y, Yang Q. The application of marogentin for the treatment of pulmonary hypertension (China, ZL201310505141.4)
3. Cao W, Wang S, Xie Y, Yang Q. The preparation method and application of grub total alkaloids (China, ZL201210101967.X)
4. Cao W, Wang S, Li Y, Xie Y, Yang Q. Bufotalin liposome, preparation method therefor and application thereof(China, ZL201210570744.8)
5. Cao W, Wang S, Xie Y, Yang Q, Zhang X. The drug combination containing tetrahydropalmatine and imperatorin and application thereof (China, ZL201110348675.1)
6. Cao W, Wang S, Xie Y, Yang Q, Sun J. Pepper kernel oil spray, preparation method therefor and application thereof (China, ZL201010184524.2)
7. Li X, Cao W, Zhao M. New effect and application of xanthophyllide in the treatment of pulmonary hypertension（ZL201410603412.4）
8. Li X, Cao W, Hou Y, Liu X, Zhao M. Gambogic acid colon controlled release tablet and its preparation method (China, ZL201210428878.6)
9. Li X, Cao W, Hou Y, Zhao M. A kind of thiazole and pyrimidine compound, preparation method therefor and application thereof (China, ZL201010179631.6)
10. Zhou X, Wang S, Xie Y, He W, Cao W, Yang Q. Stibeneglucoside injection and its preparation method (China, ZL201110196199.6)
