Dr. Dun Wang, Professor
Lab. Insect Related Resource (LIRR),
Institute of Entomology, Northwest A&F University
Address:
College of Plant Protection,
Northwest A&F University,
Xi-nong Rd. 22#,
Yang-ling, Shaanxi, 712100,
P.R.China
Contact Info:
E_mail: wanghande@nwsuaf.edu.cn; dunwang@foxmail.com
Tel. & Fax: +86-29-87091511
Dr. Wang is a Professor in Institute of Entomology in Northwest A&F University (NAFU). He received a B.S. in Forest Protection from Northwest Forestry University, in 1994 and a Ph.D. in Entomology from Zhejiang University in 2005.
Dr. Wang is Director for the Lab of Insect Related Resource at NAFU. He is a vice director of National Innovation Alliance for Forest Pest Control of National Forestry and Grassland Administration, a committee member of Forest Entomology and Resource Entomology in the Entomological Society of China and a committee member of Forest Protection Branch in Chinese Forestry Society (Biological Control Division). He received the 6th Young Scientist Award of Shaanxi Province in 2006, the 9th National Young Scientist Award in Forestry in 2007 and the 2nd Provincial Award for Achievement on Science and Investigation of Shaanxi Province in 2007. He was also granted as New Century Excellent Talent from Ministry of Education in China in 2006 for his outstanding contribution to science development in west region of China.
Dr. Wang has the active research projects in the areas of insect biochemistry and molecular biology, entomopathogens, resource insects and biological control of insect pests. In addition to overall scientific responsibility for all projects, Dun is one of the senior investigators on selected core and collaborative projects in the Institute of Entomology in NAFU.
RESEARCH INTERESTS
1. Entomopathogens and biocontrol: The functional genomics of the Baculoviruses, such as HearNPV CypoGV and OrerNPV. Based on the results of functional genomics on NPVs, we produced the genetic modified nucleopolyhedroviruses to improve biocontrol for insect pests. Another important point is the interaction between baculoviruse and its insect host, especially for the larvae behavior regulation induced by viral infection. Besides this, our lab team also focused on other pathogens against insects, including Metarhizium, Beauveria, Isaria and Bacillus for biocontrol and diversity.
2. Resource insects: Focus to honeybee diseases and herbal insects of fungal-insect complex. (1) Honeybee diseases: pathogens identification and their epidemiology, protection of honeybee from the bee disease, especially the viral diseases by using biochemical and molecular techniques. (2) The fungal-insect complex, eg. Codyceps sinensis , had a prospective potential on cancer treatment and health improvement drug development based on our previous study. We are focusing on the molecular and cellular pharmacology of these compounds and isolation of new compounds from insect herbals. Our study also cover other species of edible and herbal insects as well.
TAUGHT COURSES
Genetic Engineering, GMO, Resource Entomology, Insect Virology, Advanced Entomology, Insect physiology.
SPONSORED GRANTS
1. Study on molecular mechanisms for LdNPV triggering host insect “Tree Top Disease” mediated by Toll pathway in Lymantria dispar, National Science Foundation of China, NSFC- 32271894 (2023-2026)
2. Development of environmental friendly insecticides to control key insect pests in orchard . Shaanxi Key Project of Science and Technology, 2020zdzx03-03-02 (2020-2024)
3. Development of novel microbial insecticides for forest insect pests . National key research and development project, 2018YFD0600202-03 (2018-2021)
4. Gene therapy technology and it application for CSBV of Chinese honeybee . Innovation and Transformation Project for Agricultural Science and Technology of Shaanxi Province, NYKJ-2019-YL37 (2019-2021)
5. The study on Mechanisms of behavior manipulation by nucleopolyhedrovirus to its insect host , National Science Foundation of China, NSFC-31670659 (2017-2020)
6. Pest forecasting and sustainable pest control for armyworm. Key Grant of Science and Technology Innovation of Shaanxi Province, 2014KTCL02-14 (2015-2017)
7. Study on response mechanism against stress of drought and heavy sunlight radiation for CypoGV , National Science Foundation of China, NSFC-31270691 (2013-2016)
8. Study on genetic mechanism of overcoming pest resistance by CypoGV variation , National Science Foundation of China, NSFC-31170609 (2012-2015)
9. The study on mechanism for combined enhancement effects of HearNPV ChiA and Cry1AB on OereNPV , National Science Foundation of China, NSFC-30872033(2008-2011)
10. Studies on Chemical Characteristics of Insect Chitosan and Their Specific Bioactivities on Animal Immunity , National Science Foundation of China, NSFC-30500391 (2005)
11. Functional Analyses on ORF83, ORF86 of HearNPV , Scholar Grant of State Key Lab of Virology (P.R. China), 2006-II (2005-2007)
12. Species and Molecular Evolution of Baculovirus from Forest Pests in Northwest China , The Grant for New Century Excellent Talent (Ministry of Education, P.R. China), NCET-06-0867 (2006-2009)
PUBLICATIONS (2010-)
1. Yun Meng, P. I. Damithri Wellabada Hewage Don, Dun Wang*. A new strain of Lecanicillium uredinophilum isolated from Tibetan Plateau and its insecticidal activity. Microorganisms, 2022, 10(9): 1832 (IF 4.926)
2. Zhang J.B., Meng Y., Xu J., Rensing C., Wang D*. Effects of antibiotics on the development and intestinal bacterial diversity of black soldier fly larvae. Journal of Insects as Food and Feed, 2022, 8 (5): 495-508 (IF 5.099)
3. Liu X., Fu, Z.X, Kang Z.W., Li H., Liu T. X., Wang D*. Identification and characterization of antioxidant enzyme genes in parasitoid Aphelinus asychis (Hymenoptera: Aphelinidae) and expression profiling analysis under temperature stress. Insects, 2022, 13, 447. https://doi.org/10.3390/insects13050447 (IF 3.139)
4. Li F, Liu L, Yu X, Rensing C, Wang D*. The PI3K/AKT pathway and PTEN gene are involved in “Tree-Top Disease” of Lymantria dispar . Genes, 2022, 13, 247. (IF 4.141)
5. Long Liu, Zhilin Zhang, Chenglin Liu, Liangjian Qu, Dun Wang*. Genome analysis of an alphabaculovirus isolated from the larch looper, Erannis ankeraria . Viruses, 2022, 14 (1), 34; https://doi.org/10.3390/v14010034 (IF 5.818)
6. Jian-Wen Qiao, Yong-Liang Fan, Bing-Jin Wu1, Tian-Tian Bai, Ying-Hao Wang, Zhan-Feng Zhang, Dun Wang*, Tong-Xian Liu. Downregulation of NADPH-cytochrome P450 reductase via RNA interference increases the susceptibility of Acyrthosiphon pisum to desiccation and insecticides. Insect Science, 2022, 29(4): 1105-1119 (IF 3.605)
7. ,Liu L, Yu H, Wang D*. Genomic and biological characteristics of an alphabaculovirus isolated from Trabala vishnou gigantina . Virus Research, 2022, 308: 198630. (IF 6.286)
8. Liu L, Wei YS, Wang D*. Identification of core genes of Toll-like receptor pathway from Lymantria dispar and induced expression upon immune stimulant. Insects, 2021, 12: 827. (IF 2.769)
9. Yu X, He Q, Wang D*. Dynamic analysis of major components in the different developmental stages of Tenebrio molitor . Frontiers in Nutrition, 2021, 20: 8:689746. (IF 6.576)
10. Jian-Wen Qiao, Yong-Liang Fa, Tian-Tian Bai, Bing-Jin Wu, Xiao-Jin Pei, Dun Wang*, Tong-Xian Liu. Lipophorin receptor regulates the cuticular hydrocarbon accumulation and adult fecundity of the pea aphid Acyrthosiphon pisum. Insect Science, 2021, 28 (4):1018-1032(IF 3.262)
11. Jian-Wen Qiao, Yong-Liang Fan, Bing-Jin Wu, Dun Wang*, Tong-Xian Liu . Involvement of apolipoprotein D in desiccation tolerance and adult fecundity of Acyrthosiphon pisum . Journal of Insect Physiology, 2020, 127: 104160(IF 2.354)
12. Jian Xu, Xingyu Luo, Gangqi Fang, Shuai Zhan, Jun Wu, Dun Wang*, Yongping Huang. Transgenic expression of antimicrobial peptides from black soldier fly enhance resistance against entomopathogenic bacteria in the silkworm, Bombyx mori . Insect Biochemistry and Molecular Biology, 2020, 127, 103487(IF 4.714)
13. Jiangbin Fan, Jörg T. Wennmana, Dun Wang*, Johannes A. Jehle. Novel diversity and virulence patterns found in new isolates of Cydia pomonella granulovirus from China. Applied and Environmental Microbiology, 2020, 86 (2): e02000-19. doi: 10.1128/AEM.02000-19（IF 4.792）
14. Wu Y, Jayasekara Arachchige MN, Pei X, Wang D. Effect of WAM-1 transgenic Arabidopsis thaliana on the development and gut microbial composition of diamondback moth ( Plutella xylostella ) larvae (Lepidoptera: Plutellidae). J Appl Entomol . 2019, 143(9): 1011-1021 . https://doi. org/10.1111/jen.12674
15. Saif-Ur-Rehman, Jiyang Zheng, Nazeer Ahmed, Ji-nian Feng*, Dun Wang*. Potential of four entomopathogenic fungi isolates as biological control agents against two aphid species under laboratory conditions. Pakistan Journal of Agricultural Sciences, 2019, 56(2): 421-429
16. Saif-Ur-Rehman, Nazeer Ahmed, Ji-nian Feng*, Dun Wang*. Use of indigenous isolates of Metarhizium , Isaria and Beauveria as potential bio-control agents against Sitophilus oryzae under laboratory conditions. Pakistan Journal of Agricultural Sciences , 2019, 56(4), 1037-1044
17. Upendra Raj Bhattarai, Fengjiao Li, Mandira Katuwal Bhattarai, Abolfazl Masoudi, Dun Wang*. Phototransduction and circadian entrainment are the key pathways in the signaling mechanism for the baculovirus induced tree-top disease in the lepidopteran larvae. Scientific Reports, (2018) 8:17528 DOI:10.1038/s41598-018-35885-4
18. Mandira Katuwal Bhattarai, Upendra Raj Bhattarai, Ji-nian Feng, Dun Wang*. Effect of Different Light Spectrum in Helicoverpa armigera Larvae during HearNPV Induced Tree-Top Disease. Insects, 2018, 9, 183; doi:10.3390/insects9040183
19. Upendra Raj Bhattarai, Mandira Katuwal Bhattarai, Fengjiao Li, Dun Wang*. Insights into the temporal gene expression pattern in Lymantria dispar larvae during the baculovirus induced hyperactive stage. Virologica Sinica, (2018) 33:345–358
20. RenZW, Zhuo JC, Zhang CX, Wang D*. Characterization of NlHox3 , an essential gene for embryonic development in Nilaparvata lugens. Archives of Insect Biochemistry and Physiology, 2018, 98(2) :e21448, doi: 10.1002/arch.21448.
21. Abolfazl Masoudi, John lad Koprowski, Upendra Raj Bhattarai, Dun Wang*. Elevational distribution and morphological attributes of the entomopathogenic fungi from forests of the Qinling Mountains in China. Applied Microbiology and Biotechnology, 2018, 102(3):1483-1499
22. Jin-yi Wu, Almutamad Sheikho, He Ma, Tian-ci Li, Ya-qi Zhao, Ya-lin Zhang, Dun Wang*. Molecular mechanisms of Bombyx batryticatus ethanol extract inducing gastric cancer SGC-7901 cells apoptosis. Cytotechnology, 2017, 69(6): 875-883 DOI 10.1007/s10616-017-0102-7
23. Fan J. B., Velde S., Sun W. B., Yu H., Zhang Y. L., Wang D*. Enhanced toxicity of Cry2Ab with cantharidin and its analogues on Mythimna separata . Journal of Applied Entomology, 2017, 141(5) : 363-369. DOI: 10.1111/jen.12359
24. Huan Yu, Tong-Xian Liu, Dun Wang*. Genomic characterization and phylogenetic analysis of Chinese sacbrood virus isolated from Loess Plateau, China. Genetics and Molecular Research, 2016, 15 (3): gmr.15036928. DOI: 10.4238/gmr.15036928
25. Huan Yu, Bin Zhou, Jiao Meng, Jian Xu, Tong-Xian Liu, Dun Wang*, Recombinant Helicoverpa armigera nucleopolyhedrovirus with arthropod-specific neurotoxin gene RjAa17f from Rhopalurus junceus enhances the virulence against the host larvae. Insect Science, 2017, 24(3): 397–408. DOI 10.1111/1744-7917.12289.
26. Huan Yu, Jian Xu,, Qiang Liu,Tong-Xian Liu, Dun Wang* Ha83, a Chitin Binding Domain Encoding Gene, Is Important to Helicoverpa armigera Nucleopolyhedrovirus Budded Virus Production and Occlusion Body Assembling. Scientific Reports, 2015, 5(NO: 11088), doi:10.1038/srep11088
27. Huan Yu, Jiao Meng, Jian Xu, Tongxian Liu, Dun Wang* A novel neurotoxin gene ar1b recombination enhances the efficiency of Helicoverpa armigera nucleopolyhedrovirus as a pesticide by inhibiting the host larvae ability to feed and grow. PLOS ONE, 2015; 10(8): e0135279. DOI:10.1371/journal.pone.0135279
28. W.P. Wu, J. Cao, J.Y. Wu, H. Chen and D. Wang*. Anticancer activity of Bombyx batryticatus ethanol extract against the human tumor cell line HeLa. Genetics and Molecular Research, 2015, 14 (1): 79 - 88
29. Zheng-Wei Wu, Jiang-Bin Fan, Huan Yu, Dun Wang*, Ya-Lin Zhang. Ultraviolet protection of the Cydia pomonella granulovirus using zinc oxide and titanium dioxide. Biocontrol Science and Technology, 2015, 25(1): 97-107
30. Xiao-Feng Li, Huan Yu, Chuan-Xi Zhang, Hui Chen, Dun Wang*. Helicoverpa armigera nucleopolyhedrovirus orf81 is a late gene involved in budded virus production. Archives of Virology, 2014, 159:2011-2022
31. R.A. Khan, M. Rashid, D. Wang*, Y.L. Zhang. Antibody-based detection of alkaline phosphatase in lepidopteran insects (Lepidoptera: Noctuidae). Genetics and Molecular Research, 2013, 12 (4): 4371-4382
32. Rashid Ahmed Khan, Ji Yuan Liu, Maryam Rashid, Dun Wang*, Ya Lin Zhang. Cantharidin Impedes Activity of Glutathione S-Transferase in the Midgut of Helicoverpa armigera Hübner. International Journal of Molecular Sciences. 2013, 14, 5482-5500
33. R.A. Khan, M. Rashid, D. Wang*, Y.L. Zhang. Molecular and biochemical characterization of the effects of insecticidal toxin from meloidae beetles on Helicoverpa armigera (Hub.) (Lepidoptera: Noctuidae). Genetics and Molecular Research, 2013, 12 (4): 4393-4404
34. R.A. Khan, M. Rashid, D. Wang*, Y.L. Zhang. Toxicology and Biochemical Basis of Cantharidin Effects on Helicoverpa armigera (Hub.) (Lepidoptera: Noctuidae). Pakistan Journal of Zoology, 2013, 45(3): 769-777
35. Wei-Wei Zhang, Qiu-Rong Gao, Ming-Ming Yang, Hui Liu, Dun Wang*. Assay and characterization of an osmolarity inducible promoter newly isolated from Bacillus subtilis. Molecular Biology Reports, 2012, 39: 7347-7353（SCI）
36. Wei-Wei Zhang, Ming-Ming Yang, Heng-xin Li, Dun Wang*. Construction of recombinant Bacillus subtilis strains for efficient pimelic acid synthesis. Electronic Journal of Biotechnology, 2011,14(6): 1-9
37. Wang Yu-qin, Wang Jue, Li Jian, Liu Qiang and Huang Shi-di, Wang Dun*. Bacterial expression and purification of an active omega-atracotoxin (Ar1b) from spider Atrax robustus . Agricultural Sciences in China, 2010, 9(9): 1292-1298
