Tiltle：Prenylated compounds and Prenyltransferases
Speaker：Prof. Dr. Shu-Ming Li (InstitutfürPharmazeutischeBiologie und Biotechnologie,PhilippsUniversität Marburg, Germany)
Time：4:00 PM– 5:00 PM on Sept.25 2015（Friday）
Venue：E211 meeting room, Building of the College of Sciences
Introduction:
Shu-Ming Li, born in Henan, China, in 1961, is full professor for Pharmaceutical Biology and director of the Institute of Pharmaceutical Biology and Biotechnology at the Philipps-University in Marburg, Germany. From 1979 to 1986, he studied pharmacy and finished his master thesis on isolation of plant natural products at the Beijing University Health Science Center. He received his PhD degree in 1992 from the Rheinische Friedrich-Wilhelms-University in Bonn, Germany. The topic of his dissertation was identification of biologically active substances from algae. He spent then three years (1992-1995) for post-doc training in Freiburg and Tübingen and worked on shikonin biosynthesis in cell cultures. The research interests of Prof. Li as assistant professor at the University Tübingen from 1996 to 2006 were biosynthesis of antibiotics in bacteria, especially aminocoumarins in Streptomyces. From 2006 to 2008, Prof. Li has served as an associate professor for Pharmaceutical Biology at the Heinrich-Heine-University in Düsseldorf. His professorship in Marburg began after that in 2008.
The current research interests of Prof. Li began 2005 and focus on the genomics of the biosynthesis of secondary metabolites in fungi, especially on prenylatedindole alkaloids, e.g. ergot alkaloids and fumitremorgin-type alkaloids. Li´s group was one of the research groups, which have identified biosynthetic genes for secondary metabolites from fungal genome sequences by bioinformatic methods and proven their function by molecular biological and biochemical approaches. About 40 structure genes including those encoding prenyltransferases have been cloned, overexpressed in Saccharomyces cerevisiae or E. coli and characterized biochemically. Based on the obtained information, a large number of indole and tyrosine derivatives as well as prenylatednaphthalenes, flavonoids and acylphloroglucinols were prepared by using overproduced and purified enzymes, which provides a new strategy for production of biologically active substances.

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Sept. 23, 2015