Title: Regulation of Adipose Browning
Time: 10﹕00 am  1/6/2015（Monday）
Place: Meeting Room 107 of College of Animal Science and Technology

Shihuan Kuang
Associate Professor, Department of Animal Sciences & Center for Cancer Research.
Education
2002, PhD in University of Alberta
1992, MSc in Institute of Oceanology,Chinese Academy of Science
1989, BSc in Jiangxi University

Professional Experience

2013-  Associate Professor, Purdue University, USA
2008-2013 Assistant Professor, Purdue University,USA
2004-2007 Associate Researcher, the Sprott Center for Stem Cell Research, Canada

Current Research Interests
Adult stem cell biology
Muscle development, regeneration and neuromuscular diseases
Adipose tissue plasticity and obesity
Muscle-fat interaction.

Selected Publications

Selected from 70+ peer-reviewed publications

Kuang S, Charge SB, Seale P, Huh M, Rudnicki MA. 2006. Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol 172:103-13.
Kuang S, Kuroda K, Le Grand F, Rudnicki MA. 2007. Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell 129:999-1010. Featured by "Preview" in Cell 129(5):859-61.
Kuang S, Rudnicki MA. 2008. The emerging biology of satellite cells and their therapeutic potentials. Trends Mol Med 14: 82-91.
Kuang S, Gillespie M, Rudnicki MA. 2008. Niche regulation of muscle satellite cell self-renewal and differentiation. Cell Stem Cell 2: 22-31.
Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe H, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. 2008. PRDM16 Controls a Brown Fat/Skeletal Muscle Switch. Nature 454:961-7 (Article, Cover Picture). Science magazine’s top 10 breakthroughs of 2008
Liu W, Liu Y, Lai X, Kuang S. 2012. Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles. Dev Biol 361(1):27-38.
Wen Y, Bi P, Liu W, Asakura A, Keller C, Kuang S. 2012. Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells. Mol Cell Biol 32(12):2300-11.
Liu W, Wen Y, Bi P, Lai X, Liu XS, Liu X, Kuang S. 2012. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Development 139(16):2857-65.
Wang M, Yu H, Kim YS, Bidwell CA, Kuang S. 2012. Myostatin facilitates slow and inhibits fast myosin heavy chain expression during myogenic differentiation. Biochem Biophys Res Commun 426(1):83-8.
Hindi SM, Paul PK, Dahiya S, Mishra V, Bhatnagar S, Kuang S, Choi Y, Kumar A. 2012. Reciprocal Interaction between TRAF6 and Notch signaling regulates adult myofiber regeneration upon injury. Mol Cell Biol 32(23):4833-45.
Shan T, Liu W, Kuang S. 2013. Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues. FASEB J 27(1):277-87.
Shan T, Liang X, Bi P, Kuang S. 2013. Myostatin knockout drives browning of white adipose through activating the AMPK-PGC1a-Fndc5 pathway in muscle. FASEB J 27(5):1981-9.
Liu W, Bi P, T Shan, X Yang, Yin H, Wang YX, Liu N, Rudnicki MA, Kuang S. 2013. miR-133a regulates adipocyte browning in vivo. Plos Genet 9(7): e1003626.
Liu W, Kuang S. 2013. miR-133 links to energy balance through targeting Prdm16. J Mol Cell Biol. 5(6):432-4.
Shan T, Liang X, Bi P, Zhang P, Liu W, Kuang S. 2013. Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues. J Lipid Res 54(8):2214-24.
Liu W, Shan T, Yang X, Liu Y, Liang X, Zhang P, Liu X, Kuang S. 2013. A heterogeneous lineage origin underlies phenotypic and molecular differences of white and beige adipocytes. J Cell Sci 126(16):3527-32.
Ogura Y, Mishra V, Hindi SM, Kuang S, Kumar A. 2013. Proinflammatory cytokine TWEAK suppresses satellite cell self-renewal through inversely modulating Notch and NF-kappa B signaling pathways. J Biol Chem 288(49):35159-69.
Jiang C, Wen Y, Kuroda K, Hannon K, Rudnicki MA, Kuang S. 2014. Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy. Dis Model Mech 7(8):997-1004.
Bi P, Shan T, Liu W, Yue F, Yang X, Liang XR, Wang J, Li J, Carlesso N, Liu X, Kuang S. 2014 Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med. 20(8): 911-8. Featured by "News and Views" in Nature Medicine 20(8): 811-2 and "Editors' Choice" in Science Signaling 7:ec211.
Shan T, Zhang P, Liang X, Bi P, Kuang S. 2014. Lkb1 is indispensable for skeletal muscle development, regeneration and satellite cell homeostasis. Stem Cells 32(11):2893-907.
Zhang P, Shan T, Liang X, Deng C, Kuang S. 2014. Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochem Biophys Res Commun. 452(1):53-9.
Shan T, Zhang P, Bi P, Kuang S. 2015. Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles. J Cell Physiol. 230(5):1033-41.
Wang JH, Wang Q, Wang C, Reinholt B, Grant AL, Gerrard DE, Kuang S. 2015. Heterogeneous activation of a slow myosin gene in proliferating myoblasts and differentiated single myofibers. Dev Biol. 402(1):72-80.
Bi P, Kuang S. 2015. Notch signaling as a novel regulator of energy metabolism. Trends Endocrinol Metab. 26(5):248-255.