Personal Details
Name: Xiao Shuqi, PhD
E-mail: xiaoshuqi@nwsuaf.edu.cn
Work Address: College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, Shaanxi, 712100 China
Employment and Position
2012-present, Associate Professor and Professor of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University.
Education
Academic Visitor, 2014-2015, University of Cambridge, Cambridge, UK. Field of study: Molecular Virology and Immunology.
Post-doc, 2010-2012, Sun Yat-sen University (SYSU), Guangzhou, Guangdong. Field of study: Molecular Virology and Immunology.
Ph.D., 2010, Sun Yat-sen University (SYSU), Guangzhou, Guangdong. Field of study: Molecular Virology and Immunology.
M.S., 2007, Jilin University, Changchun, Jilin. Field of study: Animal Molecular Biology.
B.A., 2003, Henan Institute of Science and Technology, Xinxiang, Henan. Field of study: Animal Science.
Research Interests
Animal molecular virology and immunology, vaccine development, with specific reference to viral infections of the gastrointestinal tract and respiratory tract. The main focuses on RNA Virus-Host interactions and the host innate immune response to infections.
Publications published:
Angke Zhang, Hong Duan, Na Li, Lijuan Zhao, Fengxing Pu, Baicheng Huang, Chunyan Wu, Yuchen Nan, Taofeng Du, Yang Mu, Qin Zhao, Yani Sun, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*, Shuqi Xiao*. Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication. Free Radical Biology & Medicine, 2017, 102:149-161.
Angke Zhang, Lijuan Zhao, Na Li, Hong Duan, Hongliang Liu, Fengxing Pu, Gaiping Zhang, En-Min Zhou*, Shuqi Xiao*. Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the cGMP/PKG and NF-κB Signaling Pathway. Journal of Virology, 2017，91(1).
Shuqi Xiao, Xue Wang, Huaibao Ni, Na Li, Angke Zhang, Hongliang Liu, Fengxing Pu, Lele Xu, Jiming Gao, Qin Zhao, Yang Mu, Chengbao Wang, Yani Sun, Taofeng Du, Xingang Xu, Gaiping Zhang, Julian A. Hiscox, Ian G. Goodfellow, En-Min Zhou*. MiR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression. Journal of Virology, 2015, 89(8):4494-4503.
Zhiqian Ma, Fengxing Pu, Xiaobin Zhang, Yunhuan Yan, Lijuan Zhao, Angke Zhang, Na Li, En-Min Zhou, Shuqi Xiao*. Carbon Monoxide and Biliverdin Suppress Bovine Viral Diarrhoea Virus Replication. Journal of General Virology, 2017, 98(12):2982-2992.
Guangwei Zhao, Jianye Hou, Gaoxiao Xu, Aoqi Xiang, Yanmei Kang, Yunhuan Yan, Xiaobin Zhang, Gongshe Yang, Shuqi Xiao*, Shiduo Sun*. Cellular microRNA miR-10a-5p inhibits replication of porcine reproductive and respiratory syndrome virus by targeting the host factor signal recognition particle 14. Journal of General Virology, 2017, 98(4):624-632
Shuqi Xiao, Angke Zhang, Chong Zhang, Huaibo Ni, Jiming Gao, Chengbao Wang, Qin Zhao, Xiangpeng Wang, Xue Wang, Chao Ma, Hongliang Liu, Na Li, Yang Mu, Yani Sun, Gaiping Zhang, Julian A. Hiscox, Walter H. Hsu, En-Min Zhou*. Heme oxygenase-1 acts as an anti-viral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro. Antiviral Research, 2014,110:60-69.
Shuqi Xiao, Taofeng Du, Xue Wang, Huaibao Ni, Yunhuan Yan, Na Li, Chong Zhang, Angke Zhang, Jiming Gao, Hongliang Liu, Fengxing Pu, Gaiping Zhang, En-Min Zhou*. MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1. Veterinary Microbiology, 2016,192:226-230.
Na Li, Yunhuan Yan, Angke Zhang, Jiming Gao, Chong Zhang, Xue Wang, Gaopeng Hou, Gaiping Zhang, Jinbu Jia, En-Min Zhou*, Shuqi Xiao*. MicroRNA-like viral small RNA from porcine reproductive and respiratory syndrome virus negatively regulates viral replication by targeting the viral nonstructural protein 2. Oncotarget, 2016, 7(50):82902-82920.
Na Li, Taofeng Du, Yunhuan Yan, Angke Zhang, Jiming Gao, Gaopeng Hou, Shuqi Xiao*, En-Min Zhou*. MicroRNA let-7f-5p Inhibits Porcine Reproductive and Respiratory Syndrome Virus by Targeting MYH9. Scientific Reports, 2016, 6:34332. (IF: 4.259)
Chong Zhang, Fengxing Pu, Angke Zhang, Lele Xu, Na Li, Yunhuan Yan, Jiming Gao, Hongliang Liu, Gaiping Zhang, Ian G. Goodfellow, En-Min Zhou*, Shuqi Xiao*. Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro. Scientific Reports, 2015, 5:15575. (IF: 5.228)
Hongliang Liu, Yan Wang, Hong Duan, Angke Zhang, Chao Liang, Jiming Gao, Chong Zhang, Baicheng Huang, Qiongyi Li, Na Li, Shuqi Xiao *, En-Min Zhou*. An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication. Veterinary Microbiology, 2015, 181(3-4):252-260.
Liangliang Wang1, Shuqi Xiao1, Jintao Gao, Meirui Liu, Xiaoyu Zhang, Ming Li, Guangyin Zhao, Delin Mo, Xiaohong Liu, Yaosheng Chen. Inhibition of replication of porcine reproductive and respiratory syndrome virus by hemin is highly dependent on heme oxygenase-1, but independent of iron in MARC-145 cells. Antiviral research,2014, 105（5）：39-46. （1These authors contributed equally to this work）
Shuqi Xiao, Yaosheng Chen, Liangliang Wang, Jintao Gao, Delin Mo, Zuyong He, Xiaohong Liu. Simultaneous detection and differentiation of highly virulent and classical Chinese-type isolation of PRRSV by real-time RT-PCR. Journal of Immunology Research, Volume 2014 (2014), Article ID 809656, 7 pages （http://dx.doi.org/10.1155/2014/809656 ）
Jintao Gao†, Shuqi Xiao†, Xiaohong Liu, Liangliang Wang, Xiaoyu Zhang, Qianqian Ji, Yue Wang, Delin Mo, Yaosheng Chen. Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro. Virology Journal, 2014,11(1):17. （† Equal contributors）
Peiqing Cong*, Shuqi Xiao*#, Yaosheng Chen, Liangliang Wang, Jintao Gao, Ming Li, Zuyong He, Yunxue Guo, Guangyin Zhao, Xiaoyu Zhang, Luxi Chen, Delin Mo, Xiaohong Liu. Integrated miRNA and mRNA transcriptomes of porcine alveolar macrophages (PAM cells) identifies strain-specific miRNA molecular signatures associated with H-PRRSV and N-PRRSV infection. Molecular Biology Reports, 2014 ，41(9):5863-5875. （* Peiqing Cong and Shuqi Xiao have contributed equally to this work）
Shuqi Xiao, Qiwei Wang, Jintao Gao, Liangliang Wang, Zuyong He, Delin Mo, Xiaohong Liu, Yaosheng Chen. Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs. Virology Journal, 2011, 8(1):491.
Shuqi Xiao, Jianyu Jia, Delin Mo, Qiwei Wang, Limei Qin, Zuyong He, Xiao Zhao, Yuankai Huang, Anning Li, Jingwei Yu, Yuna Niu, Xiaohong Liu, Yaosheng Chen. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing. PLoS ONE, 2010, 5(6): e11377.
Shuqi Xiao, Delin Mo, Qiwei Wang, Jianyu Jia, Limei Qin, Xiangchun Yu, Yuna Niu, Xiao Zhao, Xiaohong Liu,Yaosheng Chen. Aberrant immune response in infection of pigs with the highly virulent PRRSV (H-PRRSV) identified by high-throughput digital gene expression tag profiling. BMC Genomics, 2010,11(1):544.
Shuqi Xiao, Qiwei Wang, Jianyu Jia, Peiqing Cong, Delin Mo, Xiangchun Yu, Limei Qin, Anning Li, Yuna Niu, Kongju Zhu, Xiaoying Wang, Xiaohong Liu, Yaosheng Chen. Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by Two-dimensional fluorescence difference gel electrophoresis. Virology Journal, 2010, 7(1):107.
Shuqi Xiao, Shuang Li, Jiabao Zhang, Shumin Zhang, Lisheng Dai, Yonghua Bao, Ning Jiang, Yan Gao, Zhongli Zhao, Delin Mo, Yaosheng, Chen, Zhihui Zhao. Cloning and characterization of class 1 and class 2 insulin-like growth factor-I mRNA in Songliao black pig. Molecular Biology Reports, 2009, 36(2):415-21.
Current Research Funding
National Natural Science Foundation of China: Host microRNA-10a regulatory circuitry and its molecular mechanism in regulating PRRSV infection and replication. 610,000 RMB. 2018-2021.
National Natural Science Foundation of China: Molecular mechanism of heme oxygenase 1 in the inhibition of porcine reproductive and respiratory syndrome virus replication. 830,000 RMB. 2015-2018.
National Key R&D Projects of China: Development of Novel Technologies for Prevention and Control of Major Swine Infectious Diseases. 620,000 RMB. 2017-2020.
National Key R&D Projects of China: Research and Development of New Concepts for Prevention and Control of Major Animal Diseases. 680,000 RMB. 2017-2020.
Societies
2012-present, Senior member, Chinese Society for Immunology
2011-present, Senior Member, Chinese Association of Animal Science and Veterinary Medicine (CAAV)
2017-2020, Member at the ninth council of the Branch of Animal Infectious Diseases, CAAV
2018-2023, Member at the Third council of the Branch of Veterinary Public Health, CAAV
2013-present, Senior member, Chinese Society for Microbiology, CSM
2018-2021, Young committee member of professional committee of Veterinary Microbiology, CSM
